This is a blog with Marvel fandom (The nerdy stuff), funny pictures **including but not limited too gifs and of course the occasional hatred of humanity rants.

Feel free to ask or post any of your thoughts related to Marvel i love talking nerdy.

Also my name is Shane
moistnoodles:

i-march-mello:

danim4ux:

THE SHEET IS MADE OUT OF WOOD TOO
Wendell Castle, Ghost Clock. 1985

THAT IS MAHOGANY

I thought this was a joke until I read the description

moistnoodles:

i-march-mello:

danim4ux:

THE SHEET IS MADE OUT OF WOOD TOO

Wendell Castle, Ghost Clock. 1985

THAT IS MAHOGANY

I thought this was a joke until I read the description

(Source: srsfunny, via ruinedchildhood)

Notes
144464
Posted
12 hours ago
did-you-kno:

Benedict Cumberbatch’s real-life parents play the roles of his TV parents on BBC’s Sherlock.   Source

did-you-kno:

Benedict Cumberbatch’s real-life parents play the roles of his TV parents on BBC’s Sherlock. Source

Notes
3748
Posted
13 hours ago
neurosciencestuff:

No sedative necessary: Scientists discover new “sleep node” in the brain
A sleep-promoting circuit located deep in the primitive brainstem has revealed how we fall into deep sleep. Discovered by researchers at Harvard School of Medicine and the University at Buffalo School of Medicine and Biomedical Sciences, this is only the second “sleep node” identified in the mammalian brain whose activity appears to be both necessary and sufficient to produce deep sleep.
Published online in August in Nature Neuroscience, the study demonstrates that fully half of all of the brain’s sleep-promoting activity originates from the parafacial zone (PZ) in the brainstem. The brainstem is a primordial part of the brain that regulates basic functions necessary for survival, such as breathing, blood pressure, heart rate and body temperature.
“The close association of a sleep center with other regions that are critical for life highlights the evolutionary importance of sleep in the brain,” says Caroline E. Bass, assistant professor of Pharmacology and Toxicology in the UB School of Medicine and Biomedical Sciences and a co-author on the paper.
The researchers found that a specific type of neuron in the PZ that makes the neurotransmitter gamma-aminobutyric acid (GABA) is responsible for deep sleep. They used a set of innovative tools to precisely control these neurons remotely, in essence giving them the ability to turn the neurons on and off at will.
 “These new molecular approaches allow unprecedented control over brain function at the cellular level,” says Christelle Ancelet, postdoctoral fellow at Harvard School of Medicine. “Before these tools were developed, we often used ‘electrical stimulation’ to activate a region, but the problem is that doing so stimulates everything the electrode touches and even surrounding areas it didn’t. It was a sledgehammer approach, when what we needed was a scalpel.”
“To get the precision required for these experiments, we introduced a virus into the PZ that expressed a ‘designer’ receptor on GABA neurons only but didn’t otherwise alter brain function,” explains Patrick Fuller, assistant professor at Harvard and senior author on the paper. “When we turned on the GABA neurons in the PZ, the animals quickly fell into a deep sleep without the use of sedatives or sleep aids.”
How these neurons interact in the brain with other sleep and wake-promoting brain regions still need to be studied, the researchers say, but eventually these findings may translate into new medications for treating sleep disorders, including insomnia, and the development of better and safer anesthetics.
“We are at a truly transformative point in neuroscience,” says Bass, “where the use of designer genes gives us unprecedented ability to control the brain. We can now answer fundamental questions of brain function, which have traditionally been beyond our reach, including the ‘why’ of sleep, one of the more enduring mysteries in the neurosciences.”

neurosciencestuff:

No sedative necessary: Scientists discover new “sleep node” in the brain

A sleep-promoting circuit located deep in the primitive brainstem has revealed how we fall into deep sleep. Discovered by researchers at Harvard School of Medicine and the University at Buffalo School of Medicine and Biomedical Sciences, this is only the second “sleep node” identified in the mammalian brain whose activity appears to be both necessary and sufficient to produce deep sleep.

Published online in August in Nature Neuroscience, the study demonstrates that fully half of all of the brain’s sleep-promoting activity originates from the parafacial zone (PZ) in the brainstem. The brainstem is a primordial part of the brain that regulates basic functions necessary for survival, such as breathing, blood pressure, heart rate and body temperature.

“The close association of a sleep center with other regions that are critical for life highlights the evolutionary importance of sleep in the brain,” says Caroline E. Bass, assistant professor of Pharmacology and Toxicology in the UB School of Medicine and Biomedical Sciences and a co-author on the paper.

The researchers found that a specific type of neuron in the PZ that makes the neurotransmitter gamma-aminobutyric acid (GABA) is responsible for deep sleep. They used a set of innovative tools to precisely control these neurons remotely, in essence giving them the ability to turn the neurons on and off at will.

 “These new molecular approaches allow unprecedented control over brain function at the cellular level,” says Christelle Ancelet, postdoctoral fellow at Harvard School of Medicine. “Before these tools were developed, we often used ‘electrical stimulation’ to activate a region, but the problem is that doing so stimulates everything the electrode touches and even surrounding areas it didn’t. It was a sledgehammer approach, when what we needed was a scalpel.”

“To get the precision required for these experiments, we introduced a virus into the PZ that expressed a ‘designer’ receptor on GABA neurons only but didn’t otherwise alter brain function,” explains Patrick Fuller, assistant professor at Harvard and senior author on the paper. “When we turned on the GABA neurons in the PZ, the animals quickly fell into a deep sleep without the use of sedatives or sleep aids.”

How these neurons interact in the brain with other sleep and wake-promoting brain regions still need to be studied, the researchers say, but eventually these findings may translate into new medications for treating sleep disorders, including insomnia, and the development of better and safer anesthetics.

“We are at a truly transformative point in neuroscience,” says Bass, “where the use of designer genes gives us unprecedented ability to control the brain. We can now answer fundamental questions of brain function, which have traditionally been beyond our reach, including the ‘why’ of sleep, one of the more enduring mysteries in the neurosciences.”

Notes
187
Posted
13 hours ago

googlevideos:

sex is a lot like a hot bath

once you get your balls in the worst part’s over and you can get your torso and arms and stuff in

i’ve never had sex

(Source: aidn, via fake-mermaid)

Notes
215451
Posted
13 hours ago
tmirai:

soundlyawake:

melissaannandthecool:

Just a reminder

wait…that’s…real?

Yep. A real thing. And one of their reasons was, essentially, because they don’t want employers -not- hiring women because they fear lawsuits from not paying them fair wages.
Can’t make that up.

tmirai:

soundlyawake:

melissaannandthecool:

Just a reminder

wait…that’s…real?

Yep. A real thing. And one of their reasons was, essentially, because they don’t want employers -not- hiring women because they fear lawsuits from not paying them fair wages.

Can’t make that up.

(via adumbscotts)

Notes
60760
Posted
13 hours ago

beyondhighh:

ios 8 allows you to leave group texts

image

(via ruinedchildhood)

Notes
6272
Posted
13 hours ago
dutchster:

Applying for jobs like

Dear Sir/Madam, 
Thank you for rejecting my job application to your company.
I have read your application with interest. Because I have received a large number of refusals, I had to make a selection of candidates and I regret to tell you that you are not part of this group.
Despite your qualities and experience in rejecting job applicants, I must inform you your refusal does not meet my profile for this position.
For this reason, I am notifying you I will start working for your company effective immediately. I am looking forward to a prosperous collaboration.
I wish you all the best in rejecting future applicants.
Sincerely, Mark Dutchster

dutchster:

Applying for jobs like

Dear Sir/Madam, 

Thank you for rejecting my job application to your company.

I have read your application with interest. Because I have received a large number of refusals, I had to make a selection of candidates and I regret to tell you that you are not part of this group.

Despite your qualities and experience in rejecting job applicants, I must inform you your refusal does not meet my profile for this position.

For this reason, I am notifying you I will start working for your company effective immediately. I am looking forward to a prosperous collaboration.

I wish you all the best in rejecting future applicants.

Sincerely, 
Mark Dutchster

(via dutchster)

Notes
5284
Posted
13 hours ago

shubbabang:

So I work at target now and one of my favorite things to do when I hear something in the next aisle fall is to drop what I’m doing and stand at the end of that aisle like so:

image

image

image

image

image

(via dutchster)

Notes
96844
Posted
13 hours ago

"After wrapping Guardians of the Galaxy I was very homesick and I was coming home to my wife and my son, who at the time was 13 months old. My wife told me ‘Hey, listen there’s a chance he may not recognize you and he may be a little shy’ and so I came in there, and he just sat right up and had this big smile on his face. He started saying ‘Daddy, daddy, daddy!’ and I just started to cry. He saw the tears in my eyes and started doing bits to make me laugh and that just made me cry more."

- Chris Pratt on the best day of his life.

(Source: squidward-tenassholes, via charismaticyoungaddiction)

Notes
33233
Posted
13 hours ago
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